Powerful response in joints1,2

Patient Data

Chart depicting “Adept: ACR70 Response Through Week 48"

In the above analysis, patients who withdrew or had missing values were considered nonresponders. Subjects whose dose escalated were counted as nonresponders.

All patients who completed the 24-week trial were eligible for long-term treatment in an open-label extension study (OLE)2

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Patients in the placebo group switched to HUMIRA treatment from Week 24 to Week 48
Primary endpoint of ACR20 at 12 weeks was achieved by 58% of patients treated with HUMIRA vs 14% with placebo (P<0.001)2

HUMIRA significantly inhibits joint damage3

Change in modified Total Sharp Score in psoriatic arthritis

HUMIRA (n=133) Placebo (n=141)

Week 24 Week 48 Week 24

Baseline mean 23.4 23.4 22.1

Mean change ± SD -0.1 ± 1.7 -0.2 ± 4.9† 0.9 ± 3.1

^†

P<0.001 for the difference between HUMIRA, Week 48 and placebo, Week 24 (primary analysis).

Pencil-in-cup deformity

06G-64C-Q352-7

HUMIRA is indicated for reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage and improving physical function in adult patients with moderately to severely active rheumatoid arthritis. HUMIRA is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis in patients 4 years of age and older. HUMIRA can be used alone or in combination with methotrexate. HUMIRA is indicated for reducing signs and symptoms of active arthritis, inhibiting the progression of structural damage and improving physical function in adult patients with psoriatic arthritis. HUMIRA is indicated for reducing signs and symptoms in adult patients with active ankylosing spondylitis. HUMIRA is indicated for reducing signs and symptoms and inducing and maintaining clinical remission in adult patients with moderately to severely active Crohn's disease who have had an inadequate response to conventional therapy, and reducing signs and symptoms and inducing clinical remission in these patients if they have also lost response to or are intolerant to infliximab. HUMIRA is indicated for the treatment of adult patients with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy, and when other systemic therapies are medically less appropriate. HUMIRA should only be administered to patients who will be closely monitored and have regular follow-up visits with a physician.

Please see Important Safety Information. Serious and sometimes fatal side effects have been reported with HUMIRA, including tuberculosis and other serious infections.

Please see full prescribing information.

References: 1. Gladman DD, Mease PJ, Ritchlin CT, et al. Adalimumab for long-term treatment of psoriatic arthritis: forty-eight week data from the adalimumab effectiveness in psoriatic arthritis trial. Arthritis Rheum. 2007;56:476-488. 2. Mease PJ, Gladman DD, Ritchlin CT, et al. Adalimumab for the treatment of patients with moderately to severely active psoriatic arthritis: results of a double-blind, randomized, placebo-controlled trial. Arthritis Rheum. 2005;52:3279-3289. 3. HUMIRA full prescribing information.

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